Day 040 - 21 Oct 94 - Page 16

     
     1        reports have yet been published.
     2
     3   Q.   But they are reported in this document, which is a public
     4        document?
     5        A.  If you look in the references on page 7 of the JECFA
     6        document, you will see that the reference number of the
     7        first two BIBRA reports terminates with 82, which
     8        I understand as meaning that the evidence was available in
     9        1982 and I expect that that would have been made available
    10        to the SCF in 1982, even though the documents which were
    11        submitted, at least the Butler and Conning and the Ford,
    12        Butler and Gaunt documents, were provided via the European
    13        Colours Steering Group to the World Health Organisation in
    14        1983.
    15
    16   Q.   Exactly.  It is probable, is it not, that in due course the
    17        SCF, or either, have seen that piece of work, the 90-day
    18        study, or they will have read in due course what JECFA had
    19        to say about the subject in 1984?
    20        A.  Well, I am sure the individuals on the SCF will ----
    21
    22   Q.   I am not really concerned about that, Dr. Millstone.  I am
    23        concerned with what I have described as a certain lack of
    24        objectivity, as I see it, in what you have written and the
    25        evidence you have given for this court.  You said, I think,
    26        some time ago now that one trouble with the 90-day study
    27        was that (a) it was not long-term; (b) the rats were too
    28        old.  Am I paraphrasing you correctly?
    29        A.  Not that -- the rats "may" have been too old, not that
    30        "they were".
    31
    32   Q.   You have read the rest of this report?
    33        A.  Yes.
    34
    35   Q.   Do you wish to revise that answer in relation to the
    36        conclusions drawn by this committee?
    37        A.  No, I do not.  I do not wish to revise that answer.
    38        There are some comments that I would be happy to make in
    39        respect of the Clode, Hooson, Butler and Conning study and
    40        the reanalysis by Butler and Conning.
    41
    42   Q.   Let me ask you some questions, if I may?  If I do not ask
    43        you the questions which you would like me to ask, then
    44        Mr. Morris and Ms. Steel can do it by way of
    45        re-examination.  That is the way we work in these courts,
    46        Dr. Millstone.  Am I right that an ADI of .5 milligrams per
    47        kilogram of body weight -- page 171, right-hand column --
    48        works out at 40 milligrams per day for an 80 kilogram man?
    49        A.  My mental arithmetic is not as sharp as it was when
    50        I was young, but it sounds right. 
    51 
    52   Q.   Just divide the kilograms by .5. 
    53        A.  Yes.
    54
    55   Q.   30 milligrams a day for, let us say, a 60 kilogram woman,
    56        if that is not an overestimate of women's weight; the
    57        dosages which these two generations of rats over two years,
    58        is that right?
    59        A.  That is my understanding.
    60