Day 040 - 21 Oct 94 - Page 06

     
     1                      DR. ERIK MILLSTONE, Recalled
     2                Cross-examined by MR. RAMPTON, Continued.
     3
     4   MR. RAMPTON:  Yes.  Dr. Millstone, do you have a copy of your
     5        revised statement with you?
     6        A.  I do -- no, I do not have it with me.
     7
     8   Q.   Perhaps the Defendants could provide you with a copy?
     9        (Handed).  Would you please turn to page 9?
    10        A.  Yes.
    11
    12   Q.   Please look at the second paragraph under the heading
    13        "Toxicological evaluation and possible health hazards"?
    14        A.  Yes, indeed.
    15
    16   Q.   You write:  "When the Department of Health's Committee on
    17        Toxicity (CoT) reviewed Sunset Yellow in 1979 they
    18        acknowledged that 'Certain azo-dyes including Sunset Yellow
    19        FCF have been shown to be associated with hypersensitive
    20        reactions in man'."  The only study, if I may call it that,
         which is prayed-in-aid of that statement is the study by
    22        Dr. Gert Michaelsson and others in Sweden in 1974, is it
    23        not?
    24        A.  Forgive me, is that a question?
    25
    26   Q.   I said "is it not?"
    27        A.  Sorry, I did not ----
    28
    29   Q.   Sorry, I must remember to speak up. It is, is it not, the
    30        only study so far as mankind is concerned which supports
    31        that proposition?
    32        A.  No, I do not think that is the only study.  That is the
    33        only study to which the Committee on Toxicity made
    34        reference.  It is my understanding that there are other
    35        studies, and they cited that one by way of illustration,
    36        not with the intention that that would be exhaustive.
    37
    38   Q.   Do we find those studies amongst your references?
    39        A.  Forgive me, when you say "those studies", do you mean
    40        other studies which contribute to providing evidence that
         azo-dyes have been shown to cause ----
    42
    43   Q.   Yes.
    44        A.  -- hypersensitive reactions?  Some of them, yes.
    45
    46   Q.   Which are they?
    47        A.  They are included in, I believe, the ones we were
    48        looking at and discussing in respect of BHA, because you
    49        may recall that some of the studies listed under footnote,
    50        certainly footnote 54 on page 21 referred to colours and 
    51        not just to antioxidants.  I have not exhaustively listed 
    52        in this document every possible paper to which I might have 
    53        made reference.  I simply was referring in this context to
    54        the illustration which the Committee on Toxicity had
    55        themselves chosen to cite.
    56
    57   Q.   The Michaelsson study shows, does it not, an adverse
    58        reaction in one, I think, of seven patients given repeated
    59        doses of Sunset Yellow, does it not?  You can look back, if
    60        you wish.